What’s happening at the Blood Research Program
Jing Zhang’s group described a new mechanism underlying Acute Myeloid Leukemia in Blood. BRP collaborators included David Yang, Eric Ranheim, Kirby Johnson and Emery Bresnick
Congratulations Jing and colleagues!
Shannon Kenney’s group published collaborative work with Lixin Rui and Eric Johannsen in J. Virology on the role of Tet2 in Epstein-Barr Virus latency in B cells.
Congratulations to Xin Gao, Cell and Molecular Biology grant student in the Bresnick laboratory on her highly successful thesis defense! Xin has moved to New York to pursue postdoctoral studies with Paul Frenette on the hematopoietic microenvironment, which will complement her considerable expertise in hematopoietic cell instrinsic regulatory mechanisms.
Lixin Rui’s group published a Janus Kinase 1-dependent epigenetic mechanism that regualates Diffuse Large B-cell Lymphoma in PNAS.
Congratulations Lixin and colleagues!
Congratulations to Fotis Asimakopoulos for his promotion to tenured Associate Professor of Medicine! Fotis has developed an innovative research program focusing on the role of the tumor microenvironment in immunotherapy of multiple myeloma. We are delighted to see Fotis move forward in his career development and to have him as part of the UW-Madison Blood Research Program community.
Koichi Katsumura from the Bresnick group described a new mechanism for GATA-2 to regulate Acute Myeloid Leukemia in Cell Reports!
Shannon Kenney and Jenny Gumperz continue to make strides in developing an immunotherapy approach for lymphoma.
Emery Bresnick visited the State Key Laboratory of Experimental Hematology in Tianjin, China. The Blood Research Program looks forward to developing productive and synergistic interactions with the institute and to consider hosting predoctoral and postdoctoral trainees.
Tongyu (Sophie) Wu graduates with a B.S. in Molecular Biology with distinguished accomplishments in research
Congratulations to Sophie Wu, undergraduate student in the Bresnick laboratory on her graduation and acceptance into a superb graduate program in Nutritional/Food Science. While working with Xin Gao, Sophie made important contributions and co-authored our recent publication in Stem Cell Reports describing a GATA factor/G-protein-coupled receptor regulatory circuit that controls hematopoiesis. We wish Sophie, an accomplished writer, scientist and scholar, the very best of luck with her upcoming career in Nutritional/Food Science, and look forward to following her contributions in the future.
Xin Gao publishes in Stem Cell Reports!
Congratulations to Xin Gao, graduate student in the Bresnick laboratory on her major new publication in Stem Cell Reports describing a GATA factor/G-protein-coupled receptor regulatory circuit that controls hematopoiesis. Xin will discuss these findings in an upcoming seminar at the Stem Cell and Regenerative Medicine Center of UW-Madison.
Nobuyuki Tanimura publishes in EMBO Reports
UW-Madison Blood Research Program Colloquium – 2015-2016
The schedule for the Blood Research Colloquium for 2015-2016 has been posted. Please click on the following link to view it in pdf format. Talks will be in Room 7001A WIMR at 4 PM, starting Sept. 10, 2015.
Congratulations to Nobuyuki Tanimura, postdoctoral fellow in the Bresnick laboratory on his exciting new publication in EMBO Reports describing a new mechanism in which heme amplifies GATA-1 function to establish the red cell transcriptome. Nobu presented these findings at the 2015 International Society of Experimental Hematology annual meeting in Kyoto, Japan.
Andrew DeVilbiss defends thesis
Congratulations to Andrew DeVilbiss on successfully defending his doctoral thesis in Cell and Molecular Pathology (CMP). Andrew will conduct postdoctoral research within the stem/progenitor cell biology and hematopoiesis realms in the group of Dr. Sean Morrison at UT-Southwestern. We anticipate many exciting discoveries to emerge from Andrew’s future efforts.
Kyle Hewitt publishes in Molecular Cell and is interviewed by Molecular Cell
Congratulations to Kyle Hewitt, postdoctoral fellow in the Bresnick laboratory on his important publication in Molecular Cell describing a genomic ensemble of non-coding DNA regulatory elements involved in the control of blood cell development/function and also a new signal transduction mechanism. Kyle discussed this work with the Molecular Cell editors: http://www.cell.com/molecular-cell/meet-the-author/hewitt; http://www.med.wisc.edu/news-events/research-finds-encyclopedia-of-gene-regulating-dna-that-controls-blood-cell-development/45953
Sherry Lee publishes in Nature
Huge kudos to Sherry Lee, prior graduate student in the Bresnick laboratory and current postdoctoral fellow in Harvey Lodish’s group at MIT, for her exciting publication in Nature, which was highlighted on the MIT website:
Christian Capitini receives UW-Madison scholar award
Congratulations to Christian Capitini for being awarded by the UW Provost Office for the Vilas Faculty Early Career Investigator Award, which provides $50,000 in flexible research funds for his laboratory.
Christian Capitini presents immuno-oncology research in Chicago
Congratulations to Christian Capitini for presenting one of the top abstracts by faculty at the First Annual Immuno-oncology Young Investigator’s Forum in Chicago, IL. The award includes a certificate and $1000 in flexible research funds for his laboratory.
Our colleague Hannah Mikkola, Associate Professor of Molecular, Cell and Developmental Biology at UCLA and expert in stem and progenitor cell biology/hematopoiesis, will visit and present research in the Cell and Regenerative Biology seminar series on May 27 at noon.
Our colleague John Crispino, Lurie Professor of Medicine (Hematology/Oncology) and expert in normal and malignant blood cell development, will visit and present research in Carbone Comprehensive Cancer Grand Rounds on May 13 at 8 am.
Congratulations to Andrew DeVilbiss
Congratulations to Andrew DeVilbiss on his exciting new paper published in Molecular and Cellular Biology describing an epigenetic mechanism that controls the production of red blood cells.
Congratulations to Yuan-I Chang
Congratulations to Yuan-I Chang on his important new paper published in Leukemia describing the discovery of a genetic interaction that promotes the development of myeloid leukemia.
Congratulations to Shannon Kenney
Congratulations to Shannon Kenney and colleagues for their outstanding new paper published in Journal of Clinical Investigation. In this collaboration with other Blood Research Program faculty, Jenny Gumperz, Eric Ranheim, and Fotis Asimakopoulos, the Kenney group used a humanized mouse model to gain mechanistic insights into the development of lymphoma and forged a novel foundation for translational studies to develop new lymphoma therapeutics.
Welcome Bryan Hall
Through a partnership with the UW-Madison Native American Center for Health Professions, Bryan Hall has joined the Bresnick group as a research intern. Bryan (recent University of Washington Biochemistry graduate) will conduct studies on mechanisms controlling the development and function of progenitor cells that give rise to red blood cells.
Congratulations to Deane Mosher
Congratulations to Deane Mosher who was honored as an AAAS Fellow for his sustained, outstanding contributions on mechanisms underlying cell adhesion/migration, extracellular matrix, and human disease.
More at: http://www.med.wisc.edu/news-events/23311
Congratulations to Bill Sugden
Congratulations to Dr. Bill Sugden (McArdle Laboratory for Cancer Research) for receiving a highly competitive grant from the Leukemia and Lymphoma Society to develop novel treatments for Epstein Barr Virus-dependent cancers including lymphoma.
More at: http://www.med.wisc.edu/news-events/…
Upcoming UW-Madison Blood Research Program Colloquium
A forum to discuss basic and translational discoveries on normal and malignant blood cell development and function and to promote collaborative science.
Please Click here for the 2014-15 program
Congratulations to Christian Capitini
Congratulations to Christian Capitini and his group on their new Blood paper focusing on mechanisms of graft versus host disease.
Congratulations to Igor Sluvin
Congratulations to Igor Sluvin and his group on their new Nature Communications paper describing an innovative strategy to generate differentiated blood cells from human pluripotent cells.
Christian Capitini, MD, Receives NIH-NCI Award
Congratulations to Christian Capitini, MD on receiving a National Institutes of Health-National Cancer Institute (NIH-NCI) Mentored Clinical Scientist Research Career Development Award (K08) for his project entitled “Inhibiting STAT1 as a novel graft-versus-host/graft-versus-leukemia therapy”. This proposal will provide the foundation for bringing novel drugs that target a molecule called STAT1 as a means of improving the safety and efficacy of bone marrow transplants, and ultimately improving the ability of clinicians to treat patients with high-risk or refractory leukemia. The 4 year award totals $721,440, including 75% protected research time and support of lab expenses.
Congratulations to Andrew DeVilbiss
Congratulations to Andrew DeVilbiss, Cell and Molecular Pathology graduate student in Emery Bresnick’s laboratory in the UW-Madison Blood Research Program for winning the Herbert Tabor Young Investigator Award at the Midwest Chromatin Conference. Andrew presented his work on the role of a histone methyltransferase in establishing the erythroid cell transcriptome and in controlling the development of red blood cells.
The JBC/Herbert Tabor Young Investigator Awards honor Tabor’s invaluable contributions to the journal and to science as a whole. The awards also recognize the innovators and achievers in new generations of researchers who exemplify Tabor’s values of creativity and scientific excellence. The JBC associate editors select promising young researchers at scientific symposia and meetings throughout the year. Students, postdoctoral researchers, and faculty members who’ve not yet received tenure are eligible. The award includes a plaque and a $1,500 prize.
Pictures from our UW-Madison Blood Research Program/Stem Cell and Regenerative Medicine Center Symposium
“From Stem Cells to Blood”
From Stem Cells to Blood
April 30, 2014
Upcoming Conference at Promega BioPharmaceutical Technical Institute (in Madison) on April 30 sponsored
by the UW-Madison Stem Cell and Regenerative Medicine Center and the UW-Madison Blood Research Program: Speakers include Irving Weissman (Stanford), Harvey Lodish (MIT), Nancy Speck (Penn), Emmanuelle Passegue (UCSF), David Scadden (Harvard), Paul Frenette (Einstein), Bertie Gottgens (Cambridge), Peggy Goodell (Baylor), and Scott Armstrong (Sloan Kettering).
Congratulations to Chelsea Hope and Fotis Asimakopoulos
Congratulations to Chelsea Hope (CMP Graduate Student) and Fotis Asimakopoulos on their exciting new publication in Blood: TPL2 kinase regulates the inflammatory milieu of the myeloma niche.
The -77 GATA switch site discovered by the Bresnick group (Grass et al. 2006) was demonstrated in a multi-investigator study led by the Yamamoto group at Tohoku University Medical School to cause human acute myeloid leukemia resulting from a chromosomal inversion: A remote GATA2 hematopoietic enhancer drives leukemogenesis in Inv(3)(q21:q26) by activating EVI1 expression. Yamazaki et al. Cancer Cell 2014 (See News and Views: Koche and Armstrong, Cancer Cell, April 14)
Christian Capitini, MD, Earns Early Career Faculty Travel Grant from the American Association of Immunologists
Christian Capitini, MD, recently earned a $1250 Early Career Faculty Travel Grant from the American Association of Immunologists for his abstract entitled “19F-MRI for tracking NK Cells after adoptive transfer” at their 2014 annual meeting. Congratulations Christian!
Congratulations to Sanal Kumar and colleagues
Congratulations to Sanal Kumar and colleagues for their new publication in Proc. Natl. Acad. Sci.: Mechanism governing a stem cell-generating cis-regulatory element.
Congratulations to Jing Zhang and colleagues
Congratulations to Jing Zhang and colleagues on their new paper published in Blood: Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions.
Congratulations to Jenny Gumperz and colleagues
Congratulations to Jenny Gumperz and colleagues for their recent publication describing a graft-versus-host model using humanized mice.
Mice engrafted with human fetal thymic tissue and hematopoietic stem cells develop pathology resembling chronic graft-versus-host disease. Lockridge JL, Zhou Y, Becker YA, Ma S, Kenney SC, Hematti P, Capitini CM, Burlingham WJ, Gendron-Fitzpatrick A, Gumperz JE. Biol Blood Marrow Transplant. 2013
Congratulations to Rick Eisenstein and colleagues
Congratulations to Rick Eisenstein and colleagues on their new Cell Metabolism paper, which describes a novel molecular mechanism underlying the control of erythropoiesis by iron and oxygen, and was highlighted in the American Society of Hematology publication The Hematologist. Their work has important implications for understanding and developing treatments for anemia and polycythemia vera.
Congratulations to Xin Gao
Congratulations to Xin Gao on her new J. Exp. Med. paper describing a genetic mechanism underlying the development of hematopoietic stem cells.
Congratulations to Kran Suknuntha
Congratulations to Igor Slukvin’s senior graduate student, Kran Suknuntha, who was honored at the 2013 International Society of Hematology and Stem Cell Biology meeting in Vienna for the 2nd best graduate student abstract/oral presentation.
Congratulations to Anna Beaudin
Congratulations to Anna Beaudin, postdoctoral fellow in Camilla Forsberg’s group at University of CA-Santa Cruz, who was honored at the 2013 International Society of Hematology and Stem Cell Biology meeting in Vienna for the best postdoctoral abstract/oral presentation. Camilla is an alumnus of UW-Madison, having conducted thesis research with Emery Bresnick, and was promoted recently to tenured Associate Professor at UC-Santa Cruz.
Igor Slukvin Receives $3.2 Million NIH Grant
Igor Slukvin, MD, PhD, associate professor of pathology and laboratory medicine at the University of Wisconsin School of Medicine and Public Health, received a National Institutes of Health grant to develop novel stem cell-based therapies for AIDS.
Dr. Emery Bresnick is the recipient of a Kellett Mid-Career Award
The Kellett award, supported by the Wisconsin Alumni Research Foundation, recognizes outstanding mid-career faculty members who are five to 20 years past the first promotion to a tenured position.
UW scientists will receive $340,000 a year over four years as part of the grant. Studies at the UW include clinical trials in immunotherapy and laboratory testing of protein-based agents and antibodies. UW collaborators joining Sondel on the Stand Up to Cancer Dream Team are Drs. Ken DeSantes, Christian Capitini, Mario Otto, Peiman Hematti, Alexander Rakhmilevich and Jacquelyn Hank.
- Jing Zhang has been promoted to tenured Associate Professor of Oncology
- Jing Zhang was honored with the Leukemia and Lymphoma Society Scholar Award
- Christian Capitini was honored with the UW-Madison School of Medicine and Public Heath Centennial Scholar Award
- Lixin Rui, an expert in normal and malignant B-cell development, joined the faculty of the Department of Medicine. Lixin completed postdoctoral training with Lou Staudt at the NCI and doctoral work with Chris Goodnow in Canberra.