Faculty
Deane Mosher
Eosinophil and Neutrophil Biology; Fundamental Mechanisms and Translational Strategies
We compare eosinophils and neutrophils, two terminally differentiated blood cells; describe the states of the highly condensed chromatin in these cells; learn how the cells remodel chromatin to direct changes in gene transcription needed to sustain themselves and function in inflamed tissues; and learn how chromatin in these terminally differentiated cells differs from that of the myeloid cells that are common precursors to the two cell types. In parallel, we study the structure and function of non-collagenous proteins of extracellular matrix in regulating behavior of eosinophils and other cells, with an emphasis on fibronectin, vitronectin, periostin, and TGFβ-induced globulin.
